The ECF contains roughly one-third of the total body water or about 20% of total body weight. ![]() As mentioned before, the ECF is separated from the ICF by the plasma membrane of each cell which is impermeable to nearly all classes of solutes. The Extracellular Fluid (ECF) refers the total volume of fluid outside of cells.The ICF contains roughly two-thirds of the total body water or about 40% of total body weight. Although the plasma membrane is permeable to water, it is highly impermeable to both ionic and small solutes as well as proteins. The ICF is separated from the Extracellular Fluid (see below) by the plasma membrane of each, individual cell. The Intracellular Fluid (ICF) refers to the fluid present inside cells and is considered the sum total of the fluid volume in all of the body's cells.The vascular wall is permeable to water and small solutes but not proteins. The plasma membrane is permeable to water but not small solutes or proteins. Each of these compartments is separated by the barriers shown above with unique physio-chemical properties. The ECF is itself divided between fluid within the vasculature itself, known as plasma, and that outside the vasculature, known as the interstitial fluid. The remainder is within the extracellular space as the Extracellular Fluid (ECF). Two-thirds of total body water is held within cells as Intracellular Fluid (ICF). Roughly 60% of the total body weight is water. Below we discuss how these compartments are defined, the nature of their separating barrier, and how much of the fluid volume each compartment contains in a healthy individual. ![]() In a healthy individual, fluid is divided between these functional compartments in certain ratios.
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